It'll be an adjustment for Miami, which will likely start either Ronny Turiaf or Joel Anthony at center and keep Udonis Haslem in the opening lineup at power forward -- and that trio earned a tip of the cap from Indiana coach Frank Vogel on Monday when he called them ''three of the best dirty-work guys in the business.'' James will see some time at power forward as well, which isn't uncommon for Miami anyway.
The Pacers will also be doing some adjusting as well, after spending the buildup to this series preparing for James, Wade and Bosh.
''It changes their team, but we've got to understand it doesn't allow you to play 5-on-4,'' Vogel said. ''They've got great players they can fill in for him. They've got different lineups that are sometimes more effective than the lineup with Bosh. Obviously, not having to worry about Bosh helps because he's such a terrific player.''
Indiana got a look at what Miami will do without Bosh in the second half, when James and Wade dominated the ball. James took 17 shots in the second half, Wade took 13. No other Heat player took more than two shots after halftime.
''If Chris can't play it'll be really heavy, heavy pick-and-roll sets for LeBron and D-Wade,'' Indiana forward Danny Granger said. ''That's what it was when he went out of the game. They kind of lost their low-post presence so now those guys will dominate the ball even more, which makes my job and Paul George's job a little difficult, and our bigs, because they'll set multiple pick-and-rolls every possession.''
Granger's focus Monday wasn't entirely on defense, and the extra challenge that'll come with Wade and James having the ball in their hands more now. Indiana's top scorer had no points in the first half of Game 1, his lowest since April 10, 2007 - a span of 366 games including playoffs, according to STATS LLC.
Chances are, Granger won't be taking just 10 shots again on Tuesday.
''I expect guys to always be aggressive against me,'' James said. ''We'll see. I'm always ready for a guy to be aggressive, no matter who I'm going up against. So I won't be surprised by it, if he is.''